Edward, the fifth child of Dan and Elizabeth Huntington, was born in Litchfield, Connecticut on April 25, 1807. He married Helen Maria Williams (1819-1902).

In the early 1830s, Edward lived in Northampton. In 1837, he was in Boston and in 1838 in New Brunswick. There is no evidence that Edward attended college, but his letters demonstrate some reading of the classics and a philosophical bend. In 1839, Edward and Helen Huntington settled in Cabotville, Massachusetts, near Springfield. He was a businessman and in 1841, was editor of the Cabotville Chronicle. Edward died young on October 26, 1843. He apparently had no children. He carefully preserved family letters and the collection contains many letters that Elizabeth sent to Edward, often along with pounds of butter from the farm at "Forty Acres."